Four years have passed since the events of No Way Home, and Peter Parker is now an adult living completely alone, having willingly disappeared from the lives and memories of those he loves. Fighting crime in a New York that no longer knows his name, he has devoted himself entirely to protecting his city-a full-time Spider-Man-but as the demands on him increase, the pressure triggers a startling physical evolution that threatens his existence, at the same time that a strange new pattern of crime gives rise to one of the most powerful threats he has ever faced.